Surely I am one of the many who have used the above combination of libraries. I decided to make a simple app that used the Cairngorm architecture for RIA, just to get myself up to speed. The end result is below. I faced a couple of problems deploying it to my server, primarily the Security Sandbox error. I did a blog post on that here. I have seen some people asking about this problem on FlexCoders group. Hopefully my post will be helpful to them.
BTW, you can also view the source to see the way I have used Cairngorm.